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药耐药

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However, their therapeutic use is often hindered by problems such us poor water solubility, acquired drug -resistance and strong toxicity .

但由于水溶性差、易产生多药耐药性和毒性较强等缺点限制了它们在临床上的应用。

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Conclusion : The multi-drug resistance of pathogens was a very serious problem in our ICU, especially non-fermenting Gram-negative bacilli .

结论：重症监护病房获得性感染多药耐药情况严重，尤其是非发酵革兰阴性杆菌。

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abstract: OBJECTIVE To understand the protile of mobile genetic elements in multidrug -resistant Klebsiella pneumoniae(MDR-KPN).

目的了解多药耐药肺炎克雷伯菌可移动遗传元件的存在状况。

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Conclusion : The establishment of MDR cell lines by gene transfection is an ideal method .

结论：基因转染法是建立人膀胱癌多药耐药细胞模型的理想方法。

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How to reverse MDR and improve the effectiveness of chemotherapy are important problems to be solved urgently .

如何逆转多药耐药成为提高化疗疗效的亟待解决的问题。

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Objective : To evaluate expression of the mdr1 gene and reversal of drug resistance on refractory -relapsed acute leukemia .

目的：探讨复发难治性急性白血病多药耐药性及耐药性的逆转。

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Objective To investigate retroviral -mediated transfer and expression of MDR1 gene in leukemic cells.

目的研究逆转录病毒介导多药耐药基因 MDR1 的转移与表达。

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Objective To establish a multidrug resistance cell line from human lung adenocarcinoma .

目的建立人肺腺癌多药耐药细胞系。

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It should be pay attention to the rational application of antibiotics to reduce the multi-drug resistant strains .

临床要重视并合理使用抗菌药物，减少多药耐药菌株的产生。

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Recent reports suggest that the multi drug resistance-1 (MDR1) gene is regulated by epigenetic mechanisms .

目前的报道提示多药耐药 -1 （MDR1 ）基因受渐进机制的调节。

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Multidrug resistance (MDR) of cancer cells is a major cause of failure in chemotherapy .

肿瘤化疗失败的主要原因是多药耐药（MDR ）的产生。

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These are generally reserved for use in emergencies and to combat hard-to-treat infections caused by other multi-resistant bacteria .

这些抗生素通常被储存起来以备在紧急情况下使用，用来治疗由其他多药耐药细菌产生的不易治愈的感染。

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Hence , it is very important to further study the non-classical mechanism of multidrug resistance .

因此，进一步了解非经典的耐药途径对于完善多药耐药机制有重要意义。

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In recent years, researches found that there were many kinds of cytochrome P450 enzymes which related to multidrug resistance of tumor .

目前的研究发现，有多类细胞色素 P450 酶与肿瘤多药耐药的发生密切相关。

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Objectives To study the mechanism of proteasome inhibitor -resistance and its relationship to multi-drug resistance.

目的明确蛋白酶体抑制剂硼替佐米的耐药机制及其与多药耐药的关系。

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Objective To study the expression and implication of multidrug resistance gene (MDR1) in endometrial carcinoma .

目的探讨子宫内膜癌多药耐药基因（MDR1 ）的表达及其意义。

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